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dox treatment  (MedChemExpress)


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    MedChemExpress dox treatment
    Dox Treatment, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 346 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dox treatment/product/MedChemExpress
    Average 96 stars, based on 346 article reviews
    dox treatment - by Bioz Stars, 2026-05
    96/100 stars

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    Intronic sgMYCN induces locus-specific DNA damage response and potentiates doxorubicin response. a Immuno-FISH analysis of γH2AX foci (green) and MYCN FISH signals (red) in IMR-32 A and SK-N-FI NA cells (assayed at 36–48 h). Arrows indicate representative colocalization events. Scale bar, 5 μm. b Immunofluorescence staining of phosphorylated DNA-PKcs (Ser2056, red). Scale bar, 50 μm. c Representative images from alkaline comet assays showing DNA fragmentation following sgMYCN treatment. Scale bar, 200 μm. d Quantification of DNA damage (Olive moment) from (c). e Immunofluorescence analysis of phosphorylated STING (red) in IMR-32 A and SK-N-FI NA cells. Scale bar, 50 μm. f Cell proliferation assays in IMR-32 A , LAN-5 A , SK-N-FI NA , and SK-N-AS NA cells treated with DOX, DOX + sgAAVS1, or DOX + sgMYCN ( n = 3 independent experiments). Data are mean ± s.e.m. one-way ANOVA. ( A ) denotes amplification-positive cell lines; ( NA ) non-amplified counterparts

    Journal: Molecular Cancer

    Article Title: Selective genome editing of amplified oncogenes triggers immunogenic cell death and tumor remodeling

    doi: 10.1186/s12943-025-02542-0

    Figure Lengend Snippet: Intronic sgMYCN induces locus-specific DNA damage response and potentiates doxorubicin response. a Immuno-FISH analysis of γH2AX foci (green) and MYCN FISH signals (red) in IMR-32 A and SK-N-FI NA cells (assayed at 36–48 h). Arrows indicate representative colocalization events. Scale bar, 5 μm. b Immunofluorescence staining of phosphorylated DNA-PKcs (Ser2056, red). Scale bar, 50 μm. c Representative images from alkaline comet assays showing DNA fragmentation following sgMYCN treatment. Scale bar, 200 μm. d Quantification of DNA damage (Olive moment) from (c). e Immunofluorescence analysis of phosphorylated STING (red) in IMR-32 A and SK-N-FI NA cells. Scale bar, 50 μm. f Cell proliferation assays in IMR-32 A , LAN-5 A , SK-N-FI NA , and SK-N-AS NA cells treated with DOX, DOX + sgAAVS1, or DOX + sgMYCN ( n = 3 independent experiments). Data are mean ± s.e.m. one-way ANOVA. ( A ) denotes amplification-positive cell lines; ( NA ) non-amplified counterparts

    Article Snippet: Dose-dependent treatments with DOX (S1208, Selleckchem) were applied: 0.02 μM for IMR-32 A , 0.1 μM for LAN-5 A , 0.3 μM for KELLY A , 0.5 μM for SK-N-FI NA and 1.75 μM for SK-N-AS NA . tdTomato + IMR-32 A cells were generated via transduction with LVs using the pUltra-Chili-Luc transfer plasmid (Addgene #48688), followed by cell sorting.

    Techniques: Immunofluorescence, Staining, Amplification